Trihexyphenidyl – Indications and Side Effects

drug

Trihexyphenidyl is a drug used to treat stiffness, tremors, seizures, and poor muscle control in Parkinson’s disease. Trihexyphenidyl is also used to treat and prevent the same muscle conditions caused by drugs such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), haloperidol (Haldol), thiothixene (Navane), and others.

Trihexifenidil can also be used for purposes other than those listed in this treatment guide.

Trade name : Artane, Trihexan
Generic name : Trihexyphenidyl
Preparations : Tablet 2 mg and tablet 5 mg

What is Trihexyphenidyl (Artane, Trihexane)?
Trihexifenidil converts unusual nerve impulses and relaxes stiff muscles.

What trihexifenidyl side effects might occur?
If you experience any of the following serious side effects, stop using trihexifenidil and get emergency medical help or contact your doctor immediately:

 
  • allergic reaction (difficulty in breathing, closing of the throat, swelling of the lips, tongue, or face)
  • fever
  • fast or irregular heartbeat
  • anxiety, hallucinations, confusion, agitation, hyperactivity, or loss of consciousness
  • seizure
  • sore eyes
  • rash on the skin

Other less serious side effects may be more likely. Continue to take trihexyphenidyl and discuss it with your doctor if you experience the following conditions:

  • the mouth feels dry
  • enlarged pupils or blurred vision
  • often sleepy or dizzy
  • difficulty urinating or constipation
  • nervousness or anxiety
  • stomach ache
  • sweat becomes small

This is not a complete list of side effects and others may occur. Contact your doctor for medical advice about side effects.

Be careful when driving, operating machinery, or carrying out other dangerous activities. Trihexifenidil can cause dizziness or blurred vision. If you experience dizziness or blurred vision, avoid these activities.

Use alcohol carefully. Alcohol can increase drowsiness and dizziness when taking trihexifenidil.

Avoid overheating. Trihexifenidil can cause a decrease in sweat. This can cause heat stings in the body during exercise or when exposed to the sun for a long time.

What should I discuss with my health care provider before taking trihexifenidil (Artane, Trihexane)?
Don’t use trihexyphenidyl without first talking to a doctor, or if you:

  • have experienced an allergic reaction to this drug
  • experience narrow-angle glaucoma
  • blockage in the intestine or complications of intestinal disease known as megacolon
  • myasthenia gravis

Before taking this medication, tell the doctor if you have the following conditions:

  • prostate enlargement or difficulty urinating
  • epilepsy or other seizure disorders
  • heart disease or irregular heartbeat
  • depression or other psychiatric illness
  • Kidney illness
  • liver disease

You may need special dose adjustments or monitoring during treatment if you have the requirements listed above.

It is not known whether trihexifenidyl will be harmful to unborn babies. Do not take this medicine without first talking to your doctor if you are pregnant or can become pregnant during treatment.

It is not known whether trihexyphenidyl enters ASI. Do not take this medicine without first talking to your doctor if you are breastfeeding a baby.

How to Use and Overdose

Trihexyphenidyl consumption is exactly as ordered by your doctor. If you don’t understand the doctor’s instructions, ask your pharmacist, nurse, or doctor to explain it to you in more detail.

Take each dose with a glass full of water.

Trihexifenidil can be consumed with or without food. Taking trihexifenidyl with food can reduce stomach pain.

To ensure that you get the correct dose, measure the form of trihexifenidyl syrup with a special dose or spoon cup, not with a regular spoon. If you don’t have a dosing device, ask your pharmacist where you can get it.

Store trihexifenidil at room temperature, avoid moisture and heat.

What happens if I miss a dose (Artane, Trihexane)?
Take a dose that is missed when you remember. Skip the medication if it’s almost time for the next scheduled dose. Do not take additional medication to replace missed doses.

What happens if I overdose Trihexifenidil?

Symptoms of trihexyphenidyl overdose include:

  • big pupil
  • warm and dry skin
  • flushed face
  • fever
  • dry mouth
  • fast or irregular heartbeat
  • anxiety
  • hallucinations
  • confusion
  • agitation
  • Hyperactive
  • lost consciousness
  • seizure

What should I avoid when taking Trihexifenidil (Artane, Trihexane)?
Be careful when driving, operating machinery, or carrying out other dangerous activities. Trihexifenidil can cause dizziness or blurred vision. If you experience dizziness or blurred vision, avoid this activity.

Use alcohol carefully. Alcohol can increase drowsiness and dizziness when taking trihexifenidil.

Avoid becoming too hot. Trihexifenidil can cause a decrease in sweat. This can cause heat strokes in hot weather or while exercising. Try to stay in a cool place and watch for signs of heat shock such as decreased sweating, nausea, and dizziness.

Other drugs can affect trihexifenidil (Artane and Trihexane).

Therefore, before taking this medication, tell your doctor if you take the following medications:

  • Tricyclic antidepressants (used to treat depression, pain, or obsessive-compulsive disorder) such as amitriptyline (Elavil, Endep), doxepin (Sinequan), clomipramine (Anafranil), amoxapine (Asendin), desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), or protriptyline (Vivactil)
  • Phenothiazine (used to treat mania, schizophrenia, other psychiatric conditions, and nausea and vomiting drugs) such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), thioridazine (Mellaril), promazine (Sparine), trifluoperazine (Stelazine), and others
  • Thiothixene (Navane) or chlorprothixene (Taractan)
  • Antihistamines such as diphenhydramine (Benadryl, others), chlorpheniramine (Chlor-Trimeton, others), triprolidine (Actifed, others), brompheniramine (Dimetapp, others), clemastine (Tavist), and others (antihistamines are often found in prescription drugs flu, allergies)
  • Quinidine (Quinora, Quinaglute, Quinidex, Cardioquin)
  • Amantadine (symmetrical)
  • Digoxin (Lanoxin, Lanoxicaps)
  • Haloperidol (Haldol)

You may not be able to use trihexifenidil or you may need special dose adjustments or monitoring if you use the drugs listed above.

Medications other than those listed here can also interact with trihexifenidyl. Tell your doctor about all the drugs you use. This includes medications prescribed by doctors, vitamins, herbal remedies, herbs, and the over-the-counter medications you consume without a doctor’s prescription. Don’t start a new treatment without telling your doctor.

Where can I get more information?
Your pharmacist has more information about trihexyphenidyl, or written records from your health professional that you can read.